Data report on inflammatory C–C chemokines among insulin-using women with diabetes mellitus and breast cancer

نویسندگان

  • Zachary A.P. Wintrob
  • Jeffrey P. Hammel
  • George K. Nimako
  • Zahra S. Fayazi
  • Dan P. Gaile
  • Erin E. Davis
  • Alan Forrest
  • Alice C. Ceacareanu
چکیده

Injectable insulin use may interfere with pro-inflammatory cytokines' production and, thus, play a role in the activation of tumor-associated macrophages - a process mainly influenced by inflammatory C-C chemokines. The data presented shows the relationship between pre-existing use of injectable insulin in women diagnosed with breast cancer and type 2 diabetes mellitus, the inflammatory C-C chemokine profiles at the time of breast cancer diagnosis, and subsequent cancer outcomes. A Pearson correlation analysis stratified by insulin use and controls is also provided. We present the observed relationship between the investigated C-C chemokines and between each of these biomarkers and previously reported adipokines levels in this study population [1].

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2017